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anastrozole will raise the amount or influence of exemestane by impacting hepatic/intestinal enzyme CYP3A4 metabolism. slight/importance not known. mitotane decreases levels of exemestane by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use warning/keep an eye on. Mitotane is a strong inducer of cytochrome P-4503A4; observe when coadminis